Plasmodium falciparum-Derived Uric Acid Precipitates Induce Maturation of Dendritic Cells
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Plasmodium falciparum-Derived Uric Acid Precipitates Induce Maturation of Dendritic Cells
Malaria is characterized by cyclical fevers and high levels of inflammation, and while an early inflammatory response contributes to parasite clearance, excessive and persistent inflammation can lead to severe forms of the disease. Here, we show that Plasmodium falciparum-infected erythrocytes contain uric acid precipitates in the cytoplasm of the parasitophorous vacuole, which are released whe...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0055584